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Many adults with a vague history of developing a rash or other adverse reaction to a penicillin type antibiotic as a child may actually be unnecessarily avoiding penicillins that could be ideal for treatment of a variety of bacterial infections. While we would not recommend trying penicillin again if there was a history of a severe reaction such as anaphylaxis, this may be an option for patients with a history of milder reactions such as a rash or itchy skin. For those with more severe allergies to multiple antibiotics, it is possible to desensitize to a particular antibiotic if it becomes critically needed for treatment of a severe infection.
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